Jason Maclean

Associate Professor
Websites
Research Summary
The primary focus of our group is to apply a diversity of analytical tools, including network science approaches to corticalcircuit dynamics in order to: 1) establish the higher-order cellular and synaptic mechanisms that propagate spikes, 2) to build improved encoding and decoding models of single-trial circuit activity in behaving mammals, and 3) to compare and contrast sensory and motor areas of neocortex.
Keywords
Neocortex, Visual Cortex, Motor Cortex, Graph Theory, Machine Learning, Local Circuitry
Education
  • University of Manitoba, Winnipeg CANADA, PhD Neurophysiology
Biosciences Graduate Program Association
Publications
  1. Walker JD, Pirschel F, Gidmark N, MacLean JN, Hatsopoulos NG. A platform for semi-automated voluntary training of common marmosets for behavioral neuroscience. J Neurophysiol. 2020 Mar 04. View in: PubMed

  2. Kotekal S, MacLean JN. Recurrent interactions can explain the variance in single trial responses. PLoS Comput Biol. 2020 01; 16(1):e1007591. View in: PubMed

  3. Chambers B, Levy M, Dechery JB, MacLean JN. Ensemble stacking mitigates biases in inference of synaptic connectivity. Netw Neurosci. 2018; 2(1):60-85. View in: PubMed

  4. Dechery JB, MacLean JN. Functional triplet motifs underlie accurate predictions of single-trial responses in populations of tuned and untuned V1 neurons. PLoS Comput Biol. 2018 05; 14(5):e1006153. View in: PubMed

  5. Imaizumi K, Ruthazer ES, MacLean JN, Lee CC. Editorial: Spontaneous Activity in Sensory Systems. Front Neural Circuits. 2018; 12:27. View in: PubMed

  6. Sederberg AJ, MacLean JN, Palmer SE. Learning to make external sensory stimulus predictions using internal correlations in populations of neurons. Proc Natl Acad Sci U S A. 2018 01 30; 115(5):1105-1110. View in: PubMed

  7. Dechery JB, MacLean JN. Emergent cortical circuit dynamics contain dense, interwoven ensembles of spike sequences. J Neurophysiol. 2017 09 01; 118(3):1914-1925. View in: PubMed

  8. Walker J, MacLean J, Hatsopoulos NG. The marmoset as a model system for studying voluntary motor control. Dev Neurobiol. 2017 03; 77(3):273-285. View in: PubMed

  9. Chambers B, MacLean JN. Higher-Order Synaptic Interactions Coordinate Dynamics in Recurrent Networks. PLoS Comput Biol. 2016 08; 12(8):e1005078. View in: PubMed

  10. Frye CG, MacLean JN. Spontaneous activations follow a common developmental course across primary sensory areas in mouse neocortex. J Neurophysiol. 2016 08 01; 116(2):431-7. View in: PubMed

  11. Chambers B, MacLean JN. Multineuronal activity patterns identify selective synaptic connections under realistic experimental constraints. J Neurophysiol. 2015 Sep; 114(3):1837-49. View in: PubMed

  12. Sederberg AJ, Palmer SE, MacLean JN. Decoding thalamic afferent input using microcircuit spiking activity. J Neurophysiol. 2015 Apr 01; 113(7):2921-33. View in: PubMed

  13. Neubauer FB, Sederberg A, MacLean JN. Local changes in neocortical circuit dynamics coincide with the spread of seizures to thalamus in a model of epilepsy. Front Neural Circuits. 2014; 8:101. View in: PubMed

  14. Gururangan SS, Sadovsky AJ, MacLean JN. Analysis of graph invariants in functional neocortical circuitry reveals generalized features common to three areas of sensory cortex. PLoS Comput Biol. 2014 Jul; 10(7):e1003710. View in: PubMed

  15. Sadovsky AJ, MacLean JN. Mouse visual neocortex supports multiple stereotyped patterns of microcircuit activity. J Neurosci. 2014 Jun 04; 34(23):7769-77. View in: PubMed

  16. Runfeldt MJ, Sadovsky AJ, MacLean JN. Acetylcholine functionally reorganizes neocortical microcircuits. J Neurophysiol. 2014 Sep 01; 112(5):1205-16. View in: PubMed

  17. Kruskal PB, Li L, MacLean JN. Circuit reactivation dynamically regulates synaptic plasticity in neocortex. Nat Commun. 2013; 4:2574. View in: PubMed

  18. Sadovsky AJ, MacLean JN. Scaling of topologically similar functional modules defines mouse primary auditory and somatosensory microcircuitry. J Neurosci. 2013 Aug 28; 33(35):14048-60, 14060a. View in: PubMed

  19. Piochon C, Kruskal P, Maclean J, Hansel C. Non-Hebbian spike-timing-dependent plasticity in cerebellar circuits. Front Neural Circuits. 2012; 6:124. View in: PubMed

  20. Luczak A, Maclean JN. Default activity patterns at the neocortical microcircuit level. Front Integr Neurosci. 2012; 6:30. View in: PubMed

  21. Yuste R, MacLean J, Vogelstein J, Paninski L. Imaging action potentials with calcium indicators. Cold Spring Harb Protoc. 2011 Aug 01; 2011(8):985-9. View in: PubMed

  22. Sadovsky AJ, Kruskal PB, Kimmel JM, Ostmeyer J, Neubauer FB, MacLean JN. Heuristically optimal path scanning for high-speed multiphoton circuit imaging. J Neurophysiol. 2011 Sep; 106(3):1591-8. View in: PubMed

  23. MacLean JN, Yuste R. Imaging action potentials with calcium indicators. Cold Spring Harb Protoc. 2009 Nov; 2009(11):pdb.prot5316. View in: PubMed

  24. Watson BO, MacLean JN, Yuste R. UP states protect ongoing cortical activity from thalamic inputs. PLoS One. 2008; 3(12):e3971. View in: PubMed

  25. Hoffman KL, Battaglia FP, Harris K, MacLean JN, Marshall L, Mehta MR. The upshot of up states in the neocortex: from slow oscillations to memory formation. J Neurosci. 2007 Oct 31; 27(44):11838-41. View in: PubMed

  26. MacLean JN, Fenstermaker V, Watson BO, Yuste R. A visual thalamocortical slice. Nat Methods. 2006 Feb; 3(2):129-34. View in: PubMed

  27. MacLean JN, Watson BO, Aaron GB, Yuste R. Internal dynamics determine the cortical response to thalamic stimulation. Neuron. 2005 Dec 08; 48(5):811-23. View in: PubMed

  28. Cowley KC, Zaporozhets E, Maclean JN, Schmidt BJ. Is NMDA receptor activation essential for the production of locomotor-like activity in the neonatal rat spinal cord? J Neurophysiol. 2005 Dec; 94(6):3805-14. View in: PubMed

  29. MacLean JN, Zhang Y, Goeritz ML, Casey R, Oliva R, Guckenheimer J, Harris-Warrick RM. Activity-independent coregulation of IA and Ih in rhythmically active neurons. J Neurophysiol. 2005 Nov; 94(5):3601-17. View in: PubMed

  30. Yuste R, MacLean JN, Smith J, Lansner A. The cortex as a central pattern generator. Nat Rev Neurosci. 2005 Jun; 6(6):477-83. View in: PubMed

  31. Zhang Y, MacLean JN, An WF, Lanning CC, Harris-Warrick RM. KChIP1 and frequenin modify shal-evoked potassium currents in pyloric neurons in the lobster stomatogastric ganglion. J Neurophysiol. 2003 Apr; 89(4):1902-9. View in: PubMed

  32. MacLean JN, Zhang Y, Johnson BR, Harris-Warrick RM. Activity-independent homeostasis in rhythmically active neurons. Neuron. 2003 Jan 09; 37(1):109-20. View in: PubMed

  33. MacLean JN, Schmidt BJ. Voltage-sensitivity of motoneuron NMDA receptor channels is modulated by serotonin in the neonatal rat spinal cord. J Neurophysiol. 2001 Sep; 86(3):1131-8. View in: PubMed

  34. Schmidt BJ, Hochman S, MacLean JN. NMDA receptor-mediated oscillatory properties: potential role in rhythm generation in the mammalian spinal cord. Ann N Y Acad Sci. 1998 Nov 16; 860:189-202. View in: PubMed

  35. MacLean JN, Cowley KC, Schmidt BJ. NMDA receptor-mediated oscillatory activity in the neonatal rat spinal cord is serotonin dependent. J Neurophysiol. 1998 May; 79(5):2804-8. View in: PubMed

  36. MacLean JN, Schmidt BJ, Hochman S. NMDA receptor activation triggers voltage oscillations, plateau potentials and bursting in neonatal rat lumbar motoneurons in vitro. Eur J Neurosci. 1997 Dec; 9(12):2702-11. View in: PubMed

  37. MacLean JN, Hochman S, Magnuson DS. Lamina VII neurons are rhythmically active during locomotor-like activity in the neonatal rat spinal cord. Neurosci Lett. 1995 Sep 01; 197(1):9-12. View in: PubMed

  38. Magnuson DS, Schramm MJ, MacLean JN. Long-duration, frequency-dependent motor responses evoked by ventrolateral funiculus stimulation in the neonatal rat spinal cord. Neurosci Lett. 1995 Jun 09; 192(2):97-100. View in: PubMed