Research Summary
The research in the laboratory is directed at issues of thalamic functional organization and thalamocortical relationships, mainly using the visual and somatosensory pathways in the mouse as experimental models. We use a broad interdisciplinary approach, attempting to answer the same or closely related questions with several different techniques. More specifically, we use neuroanatomical techniques to explore various circuits; we use in vitro recordings from brain slices to study cell and synaptic properties; and we record from in vivo preparations to evaluate these circuits in whole animals using an awake, behaving preparation to determine the relationship between behavioral and cognitive parameters and thalamocortical functioning. Stimulation techniques in slices include electrical activation and laser photostimulation involving both uncaging of glutamate (or GABA) and optogenetics; recording involves mainly patching of single neurons and imaging via flavoprotein autofluorescence. For in vivo recording, we use conventional single cell electrophysiology, current source density analysis, and have recently imported the technique of 2-photon calcium imaging, which enables us to follow responses of hundreds of cortical cells simultaneously. To activate or inhibit specific pathways we use optogenetics and DREAD (Designer Receptors Exclusively Activated by Designer Drugs) techniques often involving specific mouse genetic lines (e.g., involving Cre expression in transgenic mouse lines)
Keywords
Thalamus, Cortex, Cerebral, Visual Cortex, Vision, Somatosensory Cortex, Pulvinar, Lateral Geniculate Body, Ventral Posteromedial Thalamic Nucleus
Education
  • California Institute of Technology, Pasadena, CA, B.S. Biology 05/1965
  • University of Pennsylvania, Philadelphia, PA, Ph.D. Neuroanatomy 09/1969
  • Australian National University, Canberra, Australia, NA Postdoctoral training in neurophysiology 03/1972
  • Oxford University , Oxford, England, M.A. (Honorary) Neuroscience 10/1985
Biosciences Graduate Program Association
Awards & Honors
  • 1985 - 1985 Honorary M.A. degree Oxford University
  • 1985 - 1986 Newton Abraham Visiting Professor Lincoln College of Oxford University
  • 1998 - 2000 Guest Professor University of Science and Technology of China (Hefei
  • 2000 - 2001 Dr. Lee Visiting Research Fellow of Christ Church College of University of Oxford
  • 2000 - 2001 Guggenheim Fellow Guggenheim Foundation
  • 2010 - 2010 Professorial Fellow St. John’s College of Oxford University
Publications
  1. Usrey WM, Sherman SM. Corticofugal circuits: Communication lines from the cortex to the rest of the brain. J Comp Neurol. 2019 02 15; 527(3):640-650. View in: PubMed

  2. Sherman SM, Mason CA, Atabay KD, Kaas JH, LaMantia AS, Mitchell A, Walsh C. Rainer (Ray) W. Guillery 28 August 1929-7 April 2017. Eur J Neurosci. 2017 08; 46(3):1933-1936. View in: PubMed

  3. Mo C, Petrof I, Viaene AN, Sherman SM. Synaptic properties of the lemniscal and paralemniscal pathways to the mouse somatosensory thalamus. Proc Natl Acad Sci U S A. 2017 07 25; 114(30):E6212-E6221. View in: PubMed

  4. Sherman SM. Functioning of Circuits Connecting Thalamus and Cortex. Compr Physiol. 2017 03 16; 7(2):713-739. View in: PubMed

  5. Akil H, Balice-Gordon R, Cardozo DL, Koroshetz W, Posey Norris SM, Sherer T, Sherman SM, Thiels E. Neuroscience Training for the 21st Century. Neuron. 2016 06 01; 90(5):917-26. View in: PubMed

  6. Sherman SM. Thalamus plays a central role in ongoing cortical functioning. Nat Neurosci. 2016 Apr; 19(4):533-41. View in: PubMed

  7. Lam YW, Sherman SM. Functional topographic organization of the motor reticulothalamic pathway. J Neurophysiol. 2015 May 01; 113(9):3090-7. View in: PubMed

  8. Liu T, Petrof I, Sherman SM. Modulatory effects of activation of metabotropic glutamate receptors on GABAergic circuits in the mouse thalamus. J Neurophysiol. 2015 Apr 01; 113(7):2646-52. View in: PubMed

  9. Petrof I, Viaene AN, Sherman SM. Properties of the primary somatosensory cortex projection to the primary motor cortex in the mouse. J Neurophysiol. 2015 Apr 01; 113(7):2400-7. View in: PubMed

  10. Mitchell AS, Sherman SM, Sommer MA, Mair RG, Vertes RP, Chudasama Y. Advances in understanding mechanisms of thalamic relays in cognition and behavior. J Neurosci. 2014 Nov 12; 34(46):15340-6. View in: PubMed

  11. Liu T, Petrof I, Sherman SM. Modulatory effects of activation of metabotropic glutamate receptors on GABAergic circuits in the mouse cortex. J Neurophysiol. 2014 Jun 01; 111(11):2287-97. View in: PubMed

  12. Lee CC, Lam YW, Imaizumi K, Sherman SM. Laser-scanning photostimulation of optogenetically targeted forebrain circuits. J Vis Exp. 2013 Dec 27; (82):50915. View in: PubMed

  13. Lam YW, Sherman SM. Activation of both Group I and Group II metabotropic glutamatergic receptors suppress retinogeniculate transmission. Neuroscience. 2013 Jul 09; 242:78-84. View in: PubMed

  14. Sherman SM. The function of metabotropic glutamate receptors in thalamus and cortex. Neuroscientist. 2014 Apr; 20(2):136-49. View in: PubMed

  15. De Pasquale R, Sherman SM. A modulatory effect of the feedback from higher visual areas to V1 in the mouse. J Neurophysiol. 2013 May; 109(10):2618-31. View in: PubMed

  16. Viaene AN, Petrof I, Sherman SM. Activation requirements for metabotropic glutamate receptors. Neurosci Lett. 2013 Apr 29; 541:67-72. View in: PubMed

  17. Petrof I, Sherman SM. Functional significance of synaptic terminal size in glutamatergic sensory pathways in thalamus and cortex. J Physiol. 2013 Jul 01; 591(13):3125-31. View in: PubMed

  18. Lee CC, Lam YW, Sherman SM. Intracortical convergence of layer 6 neurons. Neuroreport. 2012 Aug 22; 23(12):736-40. View in: PubMed

  19. Lee CC, Sherman SM. Intrinsic modulators of auditory thalamocortical transmission. Hear Res. 2012 May; 287(1-2):43-50. View in: PubMed

  20. De Pasquale R, Sherman SM. Modulatory effects of metabotropic glutamate receptors on local cortical circuits. J Neurosci. 2012 May 23; 32(21):7364-72. View in: PubMed

  21. Sherman SM. Thalamocortical interactions. Curr Opin Neurobiol. 2012 Aug; 22(4):575-9. View in: PubMed

  22. Elmunzer BJ, Scheiman JM, Lehman GA, Chak A, Mosler P, Higgins PD, Hayward RA, Romagnuolo J, Elta GH, Sherman S, Waljee AK, Repaka A, Atkinson MR, Cote GA, Kwon RS, McHenry L, Piraka CR, Wamsteker EJ, Watkins JL, Korsnes SJ, Schmidt SE, Turner SM, Nicholson S, Fogel EL. A randomized trial of rectal indomethacin to prevent post-ERCP pancreatitis. N Engl J Med. 2012 Apr 12; 366(15):1414-22. View in: PubMed

  23. Petrof I, Viaene AN, Sherman SM. Two populations of corticothalamic and interareal corticocortical cells in the subgranular layers of the mouse primary sensory cortices. J Comp Neurol. 2012 Jun 01; 520(8):1678-86. View in: PubMed

  24. De Pasquale R, Sherman SM. Synaptic properties of corticocortical connections between the primary and secondary visual cortical areas in the mouse. J Neurosci. 2011 Nov 16; 31(46):16494-506. View in: PubMed

  25. Viaene AN, Petrof I, Sherman SM. Properties of the thalamic projection from the posterior medial nucleus to primary and secondary somatosensory cortices in the mouse. Proc Natl Acad Sci U S A. 2011 Nov 01; 108(44):18156-61. View in: PubMed

  26. Viaene AN, Petrof I, Sherman SM. Synaptic properties of thalamic input to the subgranular layers of primary somatosensory and auditory cortices in the mouse. J Neurosci. 2011 Sep 07; 31(36):12738-47. View in: PubMed

  27. Sherman SM, Guillery RW. Distinct functions for direct and transthalamic corticocortical connections. J Neurophysiol. 2011 Sep; 106(3):1068-77. View in: PubMed

  28. Lam YW, Sherman SM. Functional organization of the thalamic input to the thalamic reticular nucleus. J Neurosci. 2011 May 04; 31(18):6791-9. View in: PubMed

  29. Theyel BB, Llano DA, Issa NP, Mallik AK, Sherman SM. In vitro imaging using laser photostimulation with flavoprotein autofluorescence. Nat Protoc. 2011 Apr; 6(4):502-8. View in: PubMed

  30. Covic EN, Sherman SM. Synaptic properties of connections between the primary and secondary auditory cortices in mice. Cereb Cortex. 2011 Nov; 21(11):2425-41. View in: PubMed

  31. Lee CC, Sherman SM. On the classification of pathways in the auditory midbrain, thalamus, and cortex. Hear Res. 2011 Jun; 276(1-2):79-87. View in: PubMed

  32. Viaene AN, Petrof I, Sherman SM. Synaptic properties of thalamic input to layers 2/3 and 4 of primary somatosensory and auditory cortices. J Neurophysiol. 2011 Jan; 105(1):279-92. View in: PubMed

  33. Guillery RW, Sherman SM. Branched thalamic afferents: what are the messages that they relay to the cortex? Brain Res Rev. 2011 Jan 07; 66(1-2):205-19. View in: PubMed

  34. Theyel BB, Lee CC, Sherman SM. Specific and nonspecific thalamocortical connectivity in the auditory and somatosensory thalamocortical slices. Neuroreport. 2010 Sep 15; 21(13):861-4. View in: PubMed

  35. Lee CC, Sherman SM. Drivers and modulators in the central auditory pathways. Front Neurosci. 2010 Apr 15; 4:79. View in: PubMed

  36. Lee CC, Sherman SM. Topography and physiology of ascending streams in the auditory tectothalamic pathway. Proc Natl Acad Sci U S A. 2010 Jan 05; 107(1):372-7. View in: PubMed

  37. Theyel BB, Llano DA, Sherman SM. The corticothalamocortical circuit drives higher-order cortex in the mouse. Nat Neurosci. 2010 Jan; 13(1):84-8. View in: PubMed

  38. Lu E, Llano DA, Sherman SM. Different distributions of calbindin and calretinin immunostaining across the medial and dorsal divisions of the mouse medial geniculate body. Hear Res. 2009 Nov; 257(1-2):16-23. View in: PubMed

  39. Petrof I, Sherman SM. Synaptic properties of the mammillary and cortical afferents to the anterodorsal thalamic nucleus in the mouse. J Neurosci. 2009 Jun 17; 29(24):7815-9. View in: PubMed

  40. Lam YW, Sherman SM. Functional organization of the somatosensory cortical layer 6 feedback to the thalamus. Cereb Cortex. 2010 Jan; 20(1):13-24. View in: PubMed

  41. Llano DA, Sherman SM. Differences in intrinsic properties and local network connectivity of identified layer 5 and layer 6 adult mouse auditory corticothalamic neurons support a dual corticothalamic projection hypothesis. Cereb Cortex. 2009 Dec; 19(12):2810-26. View in: PubMed

  42. Llano DA, Theyel BB, Mallik AK, Sherman SM, Issa NP. Rapid and sensitive mapping of long-range connections in vitro using flavoprotein autofluorescence imaging combined with laser photostimulation. J Neurophysiol. 2009 Jun; 101(6):3325-40. View in: PubMed

  43. Lee CC, Sherman SM. Modulator property of the intrinsic cortical projection from layer 6 to layer 4. Front Syst Neurosci. 2009; 3:3. View in: PubMed

  44. Lee CC, Sherman SM. Glutamatergic inhibition in sensory neocortex. Cereb Cortex. 2009 Oct; 19(10):2281-9. View in: PubMed

  45. Varela C, Sherman SM. Differences in response to serotonergic activation between first and higher order thalamic nuclei. Cereb Cortex. 2009 Aug; 19(8):1776-86. View in: PubMed

  46. Lee CC, Sherman SM. Synaptic properties of thalamic and intracortical inputs to layer 4 of the first- and higher-order cortical areas in the auditory and somatosensory systems. J Neurophysiol. 2008 Jul; 100(1):317-26. View in: PubMed

  47. Llano DA, Sherman SM. Evidence for nonreciprocal organization of the mouse auditory thalamocortical-corticothalamic projection systems. J Comp Neurol. 2008 Mar 10; 507(2):1209-27. View in: PubMed

  48. Varela C, Sherman SM. Differences in response to muscarinic activation between first and higher order thalamic relays. J Neurophysiol. 2007 Dec; 98(6):3538-47. View in: PubMed

  49. Lam YW, Sherman SM. Different topography of the reticulothalmic inputs to first- and higher-order somatosensory thalamic relays revealed using photostimulation. J Neurophysiol. 2007 Nov; 98(5):2903-9. View in: PubMed

  50. Sherman SM. The thalamus is more than just a relay. Curr Opin Neurobiol. 2007 Aug; 17(4):417-22. View in: PubMed

  51. Van Horn SC, Sherman SM. Fewer driver synapses in higher order than in first order thalamic relays. Neuroscience. 2007 Apr 25; 146(1):463-70. View in: PubMed

  52. Kay LM, Sherman SM. An argument for an olfactory thalamus. Trends Neurosci. 2007 Feb; 30(2):47-53. View in: PubMed

  53. Lam YW, Nelson CS, Sherman SM. Mapping of the functional interconnections between thalamic reticular neurons using photostimulation. J Neurophysiol. 2006 Nov; 96(5):2593-600. View in: PubMed

  54. Sherman SM. The neural substrates of cognition. Trends Neurosci. 2006 Jun; 29(6):295-7. View in: PubMed

  55. Sherman SM. Thalamic relays and cortical functioning. Prog Brain Res. 2005; 149:107-26. View in: PubMed

  56. Lam YW, Sherman SM. Mapping by laser photostimulation of connections between the thalamic reticular and ventral posterior lateral nuclei in the rat. J Neurophysiol. 2005 Oct; 94(4):2472-83. View in: PubMed

  57. Ramcharan EJ, Gnadt JW, Sherman SM. Higher-order thalamic relays burst more than first-order relays. Proc Natl Acad Sci U S A. 2005 Aug 23; 102(34):12236-41. View in: PubMed

  58. Lam YW, Cox CL, Varela C, Sherman SM. Morphological correlates of triadic circuitry in the lateral geniculate nucleus of cats and rats. J Neurophysiol. 2005 Feb; 93(2):748-57. View in: PubMed

  59. Sherman SM. Interneurons and triadic circuitry of the thalamus. Trends Neurosci. 2004 Nov; 27(11):670-5. View in: PubMed

  60. Van Horn SC, Sherman SM. Differences in projection patterns between large and small corticothalamic terminals. J Comp Neurol. 2004 Jul 26; 475(3):406-15. View in: PubMed

  61. Reichova I, Sherman SM. Somatosensory corticothalamic projections: distinguishing drivers from modulators. J Neurophysiol. 2004 Oct; 92(4):2185-97. View in: PubMed

  62. Cox CL, Reichova I, Sherman SM. Functional synaptic contacts by intranuclear axon collaterals of thalamic relay neurons. J Neurosci. 2003 Aug 20; 23(20):7642-6. View in: PubMed

  63. Killackey HP, Sherman SM. Corticothalamic projections from the rat primary somatosensory cortex. J Neurosci. 2003 Aug 13; 23(19):7381-4. View in: PubMed

  64. Ramcharan EJ, Gnadt JW, Sherman SM. Single-unit recording in the lateral geniculate nucleus of the awake behaving monkey. Methods. 2003 Jun; 30(2):142-51. View in: PubMed

  65. Guillery RW, Sherman SM. The thalamus as a monitor of motor outputs. Philos Trans R Soc Lond B Biol Sci. 2002 Dec 29; 357(1428):1809-21. View in: PubMed

  66. Sherman SM, Guillery RW. The role of the thalamus in the flow of information to the cortex. Philos Trans R Soc Lond B Biol Sci. 2002 Dec 29; 357(1428):1695-708. View in: PubMed

  67. Smith GD, Sherman SM. Detectability of excitatory versus inhibitory drive in an integrate-and-fire-or-burst thalamocortical relay neuron model. J Neurosci. 2002 Dec 01; 22(23):10242-50. View in: PubMed

  68. Guillery RW, Sherman SM. Thalamic relay functions and their role in corticocortical communication: generalizations from the visual system. Neuron. 2002 Jan 17; 33(2):163-75. View in: PubMed

  69. Wang S, Bickford ME, Van Horn SC, Erisir A, Godwin DW, Sherman SM. Synaptic targets of thalamic reticular nucleus terminals in the visual thalamus of the cat. J Comp Neurol. 2001 Nov 26; 440(4):321-41. View in: PubMed

  70. Sherman SM. Thalamic relay functions. Prog Brain Res. 2001; 134:51-69. View in: PubMed

  71. Ramcharan EJ, Gnadt JW, Sherman SM. The effects of saccadic eye movements on the activity of geniculate relay neurons in the monkey. Vis Neurosci. 2001 Mar-Apr; 18(2):253-8. View in: PubMed

  72. Levitt JB, Schumer RA, Sherman SM, Spear PD, Movshon JA. Visual response properties of neurons in the LGN of normally reared and visually deprived macaque monkeys. J Neurophysiol. 2001 May; 85(5):2111-29. View in: PubMed

  73. Sherman SM. Tonic and burst firing: dual modes of thalamocortical relay. Trends Neurosci. 2001 Feb; 24(2):122-6. View in: PubMed

  74. Gutierrez C, Cox CL, Rinzel J, Sherman SM. Dynamics of low-threshold spike activation in relay neurons of the cat lateral geniculate nucleus. J Neurosci. 2001 Feb 01; 21(3):1022-32. View in: PubMed

  75. Cox CL, Sherman SM. Control of dendritic outputs of inhibitory interneurons in the lateral geniculate nucleus. Neuron. 2000 Sep; 27(3):597-610. View in: PubMed

  76. Ramcharan EJ, Cox CL, Zhan XJ, Sherman SM, Gnadt JW. Cellular mechanisms underlying activity patterns in the monkey thalamus during visual behavior. J Neurophysiol. 2000 Oct; 84(4):1982-7. View in: PubMed

  77. Bickford ME, Ramcharan E, Godwin DW, Erisir A, Gnadt J, Sherman SM. Neurotransmitters contained in the subcortical extraretinal inputs to the monkey lateral geniculate nucleus. J Comp Neurol. 2000 Sep 04; 424(4):701-17. View in: PubMed

  78. Sherman SM. A new slant on the development of orientation selectivity. Nat Neurosci. 2000 Jun; 3(6):525-7. View in: PubMed

  79. Zhan XJ, Cox CL, Sherman SM. Dendritic depolarization efficiently attenuates low-threshold calcium spikes in thalamic relay cells. J Neurosci. 2000 May 15; 20(10):3909-14. View in: PubMed

  80. Ramcharan EJ, Gnadt JW, Sherman SM. Burst and tonic firing in thalamic cells of unanesthetized, behaving monkeys. Vis Neurosci. 2000 Jan-Feb; 17(1):55-62. View in: PubMed

  81. Van Horn SC, Erisir A, Sherman SM. Relative distribution of synapses in the A-laminae of the lateral geniculate nucleus of the cat. J Comp Neurol. 2000 Jan 24; 416(4):509-20. View in: PubMed

  82. Smith GD, Cox CL, Sherman SM, Rinzel J. Fourier analysis of sinusoidally driven thalamocortical relay neurons and a minimal integrate-and-fire-or-burst model. J Neurophysiol. 2000 Jan; 83(1):588-610. View in: PubMed

  83. Cox CL, Sherman SM. Glutamate inhibits thalamic reticular neurons. J Neurosci. 1999 Aug 01; 19(15):6694-9. View in: PubMed

  84. Reinagel P, Godwin D, Sherman SM, Koch C. Encoding of visual information by LGN bursts. J Neurophysiol. 1999 May; 81(5):2558-69. View in: PubMed

  85. Zhan XJ, Cox CL, Rinzel J, Sherman SM. Current clamp and modeling studies of low-threshold calcium spikes in cells of the cat's lateral geniculate nucleus. J Neurophysiol. 1999 May; 81(5):2360-73. View in: PubMed

  86. Lo FS, Sherman SM. [Acetylcholine decreases low threshold T-type calcium conductance of relay cells in the cat's lateral geniculate nucleus]. Sheng Li Xue Bao. 1997 Jun; 49(3):307-13. View in: PubMed

  87. Luo F, Sherman SM. Kinetics of low threshold calcium channels of relay cells in cat lateral geniculate nucleus. Sci China C Life Sci. 1996 Dec; 39(6):645-51. View in: PubMed

  88. Cox CL, Zhou Q, Sherman SM. Glutamate locally activates dendritic outputs of thalamic interneurons. Nature. 1998 Jul 30; 394(6692):478-82. View in: PubMed

  89. Sherman SM, Guillery RW. On the actions that one nerve cell can have on another: distinguishing "drivers" from "modulators". Proc Natl Acad Sci U S A. 1998 Jun 09; 95(12):7121-6. View in: PubMed

  90. Guido W, Sherman SM. Response latencies of cells in the cat's lateral geniculate nucleus are less variable during burst than tonic firing. Vis Neurosci. 1998 Mar-Apr; 15(2):231-7. View in: PubMed

  91. Erisir A, Van Horn SC, Sherman SM. Distribution of synapses in the lateral geniculate nucleus of the cat: differences between laminae A and A1 and between relay cells and interneurons. J Comp Neurol. 1998 Jan 12; 390(2):247-55. View in: PubMed

  92. Erisir A, Van Horn SC, Sherman SM. Relative numbers of cortical and brainstem inputs to the lateral geniculate nucleus. Proc Natl Acad Sci U S A. 1997 Feb 18; 94(4):1517-20. View in: PubMed

  93. Erisir A, Van Horn SC, Bickford ME, Sherman SM. Immunocytochemistry and distribution of parabrachial terminals in the lateral geniculate nucleus of the cat: a comparison with corticogeniculate terminals. J Comp Neurol. 1997 Jan 27; 377(4):535-49. View in: PubMed

  94. Godwin DW, Van Horn SC, Eriir A, Sesma M, Romano C, Sherman SM. Ultrastructural localization suggests that retinal and cortical inputs access different metabotropic glutamate receptors in the lateral geniculate nucleus. J Neurosci. 1996 Dec 15; 16(24):8181-92. View in: PubMed

  95. Godwin DW, Vaughan JW, Sherman SM. Metabotropic glutamate receptors switch visual response mode of lateral geniculate nucleus cells from burst to tonic. J Neurophysiol. 1996 Sep; 76(3):1800-16. View in: PubMed

  96. Sherman SM, Guillery RW. Functional organization of thalamocortical relays. J Neurophysiol. 1996 Sep; 76(3):1367-95. View in: PubMed

  97. Sherman SM. Dual response modes in lateral geniculate neurons: mechanisms and functions. Vis Neurosci. 1996 Mar-Apr; 13(2):205-13. View in: PubMed

  98. Guido W, Lu SM, Vaughan JW, Godwin DW, Sherman SM. Receiver operating characteristic (ROC) analysis of neurons in the cat's lateral geniculate nucleus during tonic and burst response mode. Vis Neurosci. 1995 Jul-Aug; 12(4):723-41. View in: PubMed

  99. Cucchiaro JB, Uhlrich DJ, Sherman SM. Ultrastructure of synapses from the pretectum in the A-laminae of the cat's lateral geniculate nucleus. J Comp Neurol. 1993 Aug 22; 334(4):618-30. View in: PubMed

  100. Lu SM, Guido W, Sherman SM. The brain-stem parabrachial region controls mode of response to visual stimulation of neurons in the cat's lateral geniculate nucleus. Vis Neurosci. 1993 Jul-Aug; 10(4):631-42. View in: PubMed

  101. Murphy PC, Uhlrich DJ, Tamamaki N, Sherman SM. Brain-stem modulation of the response properties of cells in the cat's perigeniculate nucleus. Vis Neurosci. 1994 Jul-Aug; 11(4):781-91. View in: PubMed

  102. Günlük AE, Bickford ME, Sherman SM. Rearing with monocular lid suture induces abnormal NADPH-diaphorase staining in the lateral geniculate nucleus of cats. J Comp Neurol. 1994 Dec 08; 350(2):215-28. View in: PubMed

  103. Bickford ME, Günlük AE, Van Horn SC, Sherman SM. GABAergic projection from the basal forebrain to the visual sector of the thalamic reticular nucleus in the cat. J Comp Neurol. 1994 Oct 22; 348(4):481-510. View in: PubMed

  104. Lo FS, Sherman SM. Feedback inhibition in the cat's lateral geniculate nucleus. Exp Brain Res. 1994; 100(2):365-8. View in: PubMed

  105. Bickford ME, Günlük AE, Guido W, Sherman SM. Evidence that cholinergic axons from the parabrachial region of the brainstem are the exclusive source of nitric oxide in the lateral geniculate nucleus of the cat. J Comp Neurol. 1993 Aug 15; 334(3):410-30. View in: PubMed

  106. Uhlrich DJ, Tamamaki N, Murphy PC, Sherman SM. Effects of brain stem parabrachial activation on receptive field properties of cells in the cat's lateral geniculate nucleus. J Neurophysiol. 1995 Jun; 73(6):2428-47. View in: PubMed

  107. Tamamaki N, Uhlrich DJ, Sherman SM. Morphology of physiologically identified retinal X and Y axons in the cat's thalamus and midbrain as revealed by intraaxonal injection of biocytin. J Comp Neurol. 1995 Apr 17; 354(4):583-607. View in: PubMed

  108. Lu SM, Guido W, Vaughan JW, Sherman SM. Latency variability of responses to visual stimuli in cells of the cat's lateral geniculate nucleus. Exp Brain Res. 1995; 105(1):7-17. View in: PubMed

  109. Lehmkuhle S, Kratz KE, Mangel SC, Sherman SM. Effects of early monocular lid suture on spatial and temporal sensitivity of neurons in dorsal lateral geniculate nucleus of the cat. J Neurophysiol. 1980 Feb; 43(2):542-56. View in: PubMed

  110. Lehmkuhle S, Kratz KE, Mangel SC, Sherman SM. Spatial and temporal sensitivity of X- and Y-cells in dorsal lateral geniculate nucleus of the cat. J Neurophysiol. 1980 Feb; 43(2):520-41. View in: PubMed

  111. Stanford LR, Friedlander MJ, Sherman SM. Morphology of physiologically identified W-cells in the C laminae of the cat's lateral geniculate nucleus. J Neurosci. 1981 Jun; 1(6):578-84. View in: PubMed

  112. Friedlander MJ, Lin CS, Stanford LR, Sherman SM. Morphology of functionally identified neurons in lateral geniculate nucleus of the cat. J Neurophysiol. 1981 Jul; 46(1):80-129. View in: PubMed

  113. Sherman SM, Wilson JR. Further evidence of an early critical period in the development of the cat's dorsal lateral geniculate nucleus. J Comp Neurol. 1981 Mar 01; 196(3):459-70. View in: PubMed

  114. Lehmkuhle S, Kratz KE, Sherman SM. Spatial and temporal sensitivity of normal and amblyopic cats. J Neurophysiol. 1982 Aug; 48(2):372-87. View in: PubMed

  115. Sur M, Sherman SM. Linear and nonlinear W-cells in C-laminae of the cat's lateral geniculate nucleus. J Neurophysiol. 1982 May; 47(5):869-84. View in: PubMed

  116. Wilson JR, Tessin DE, Sherman SM. Development of the electrophysiological properties of Y-cells in the kitten's medial interlaminar nucleus. J Neurosci. 1982 May; 2(5):562-71. View in: PubMed

  117. Friedlander MJ, Stanford LR, Sherman SM. Effects of monocular deprivation on the structure-function relationship of individual neurons in the cat's lateral geniculate nucleus. J Neurosci. 1982 Mar; 2(3):321-30. View in: PubMed

  118. Mangel SC, Wilson JR, Sherman SM. Development of neuronal response properties in the cat dorsal lateral geniculate nucleus during monocular deprivation. J Neurophysiol. 1983 Jul; 50(1):240-64. View in: PubMed

  119. Stanford LR, Friedlander MJ, Sherman SM. Morphological and physiological properties of geniculate W-cells of the cat: a comparison with X- and Y-cells. J Neurophysiol. 1983 Sep; 50(3):582-608. View in: PubMed

  120. Lehmkuhle S, Sherman SM, Kratz KE. Spatial contrast sensitivity of dark-reared cats with striate cortex lesions. J Neurosci. 1984 Oct; 4(10):2419-24. View in: PubMed

  121. Sur M, Weller RE, Sherman SM. Development of X- and Y-cell retinogeniculate terminations in kittens. Nature. 1984 Jul 19-25; 310(5974):246-9. View in: PubMed

  122. Sherman SM, Spear PD. Organization of visual pathways in normal and visually deprived cats. Physiol Rev. 1982 Apr; 62(2):738-855. View in: PubMed

  123. Wilson JR, Friedlander MJ, Sherman SM. Fine structural morphology of identified X- and Y-cells in the cat's lateral geniculate nucleus. Proc R Soc Lond B Biol Sci. 1984 Jun 22; 221(1225):411-36. View in: PubMed

  124. Sanderson KJ, Sherman SM. Nasotemporal overlap in visual field projected to lateral geniculate nucleus in the cat. J Neurophysiol. 1971 May; 34(3):453-66. View in: PubMed

  125. Sherman SM, Sanderson KJ. Binocular interaction on cells of the dorsal lateral geniculate nucleus of visually deprived cats. Brain Res. 1972 Feb 11; 37(1):126-31. View in: PubMed

  126. Sherman SM, Hoffmann KP, Stone J. Loss of a specific cell type from dorsal lateral geniculate nucleus in visually deprived cats. J Neurophysiol. 1972 Jul; 35(4):532-41. View in: PubMed

  127. Hoffmann KP, Sherman SM. Effects of early monocular deprivation on visual input to cat superior colliculus. J Neurophysiol. 1974 Nov; 37(6):1276-86. View in: PubMed

  128. Sherman SM, Guillery RW, Kaas JH, Sanderson KJ. Behavioral, electrophysiological and morphological studies of binocular competition in the development of the geniculo-cortical pathways of cats. J Comp Neurol. 1974 Nov 01; 158(1):1-18. View in: PubMed

  129. Hoffmann KP, Stone J, Sherman SM. Relay of receptive-field properties in dorsal lateral geniculate nucleus of the cat. J Neurophysiol. 1972 Jul; 35(4):518-31. View in: PubMed

  130. Stone J, Leicester J, Sherman SM. The naso-temporal division of the monkey's retina. J Comp Neurol. 1973 Aug; 150(3):333-48. View in: PubMed

  131. Hamos JE, Van Horn SC, Raczkowski D, Uhlrich DJ, Sherman SM. Synaptic connectivity of a local circuit neurone in lateral geniculate nucleus of the cat. Nature. 1985 Oct 17-23; 317(6038):618-21. View in: PubMed

  132. Humphrey AL, Sur M, Uhlrich DJ, Sherman SM. Termination patterns of individual X- and Y-cell axons in the visual cortex of the cat: projections to area 18, to the 17/18 border region, and to both areas 17 and 18. J Comp Neurol. 1985 Mar 08; 233(2):190-212. View in: PubMed

  133. Humphrey AL, Sur M, Uhlrich DJ, Sherman SM. Projection patterns of individual X- and Y-cell axons from the lateral geniculate nucleus to cortical area 17 in the cat. J Comp Neurol. 1985 Mar 08; 233(2):159-89. View in: PubMed

  134. Hsiao CF, Sherman SM. Alpha and beta cells projecting from retina to lamina A of the lateral geniculate nucleus in normal cats, monocularly deprived cats, and young kittens. Exp Brain Res. 1986; 61(2):413-31. View in: PubMed

  135. Garraghty PE, Sur M, Sherman SM. Role of competitive interactions in the postnatal development of X and Y retinogeniculate axons. J Comp Neurol. 1986 Sep 08; 251(2):216-39. View in: PubMed

  136. Garraghty PE, Sur M, Weller RE, Sherman SM. Morphology of retinogeniculate X and Y axon arbors in monocularly enucleated cats. J Comp Neurol. 1986 Sep 08; 251(2):198-215. View in: PubMed

  137. Sur M, Esguerra M, Garraghty PE, Kritzer MF, Sherman SM. Morphology of physiologically identified retinogeniculate X- and Y-axons in the cat. J Neurophysiol. 1987 Jul; 58(1):1-32. View in: PubMed

  138. Hamos JE, Van Horn SC, Raczkowski D, Sherman SM. Synaptic circuits involving an individual retinogeniculate axon in the cat. J Comp Neurol. 1987 May 08; 259(2):165-92. View in: PubMed

  139. Raczkowski D, Hamos JE, Sherman SM. Synaptic circuitry of physiologically identified W-cells in the cat's dorsal lateral geniculate nucleus. J Neurosci. 1988 Jan; 8(1):31-48. View in: PubMed

  140. Bloomfield SA, Hamos JE, Sherman SM. Passive cable properties and morphological correlates of neurones in the lateral geniculate nucleus of the cat. J Physiol. 1987 Feb; 383:653-92. View in: PubMed

  141. Bloomfield SA, Sherman SM. Postsynaptic potentials recorded in neurons of the cat's lateral geniculate nucleus following electrical stimulation of the optic chiasm. J Neurophysiol. 1988 Dec; 60(6):1924-45. View in: PubMed

  142. Sherman SM, Friedlander MJ. Identification of X versus Y properties for interneurons in the A-laminae of the cat's lateral geniculate nucleus. Exp Brain Res. 1988; 73(2):384-92. View in: PubMed

  143. Cucchiaro JB, Uhlrich DJ, Sherman SM. Parabrachial innervation of the cat's dorsal lateral geniculate nucleus: an electron microscopic study using the tracer Phaseolus vulgaris leucoagglutinin (PHA-L). J Neurosci. 1988 Dec; 8(12):4576-88. View in: PubMed

  144. Sherman SM, Koch C. The control of retinogeniculate transmission in the mammalian lateral geniculate nucleus. Exp Brain Res. 1986; 63(1):1-20. View in: PubMed

  145. Raczkowski D, Sherman SM. Morphology and physiology of single neurons in the medial interlaminar nucleus of the cat's lateral geniculate nucleus. J Neurosci. 1985 Oct; 5(10):2702-18. View in: PubMed

  146. Uhlrich DJ, Cucchiaro JB, Sherman SM. The projection of individual axons from the parabrachial region of the brain stem to the dorsal lateral geniculate nucleus in the cat. J Neurosci. 1988 Dec; 8(12):4565-75. View in: PubMed

  147. Bloomfield SA, Sherman SM. Dendritic current flow in relay cells and interneurons of the cat's lateral geniculate nucleus. Proc Natl Acad Sci U S A. 1989 May; 86(10):3911-4. View in: PubMed

  148. Raczkowski D, Uhlrich DJ, Sherman SM. Morphology of retinogeniculate X and Y axon arbors in cats raised with binocular lid suture. J Neurophysiol. 1988 Dec; 60(6):2152-67. View in: PubMed

  149. Lo FS, Sherman SM. In vivo recording of postsynaptic potentials and low threshold spikes in W cells of the cat's lateral geniculate nucleus. Exp Brain Res. 1990; 81(2):438-42. View in: PubMed

  150. Uhlrich DJ, Tamamaki N, Sherman SM. Brainstem control of response modes in neurons of the cat's lateral geniculate nucleus. Proc Natl Acad Sci U S A. 1990 Apr; 87(7):2560-3. View in: PubMed

  151. Lo FS, Lu SM, Sherman SM. Intracellular and extracellular in vivo recording of different response modes for relay cells of the cat's lateral geniculate nucleus. Exp Brain Res. 1991; 83(2):317-28. View in: PubMed

  152. Scharfman HE, Lu SM, Guido W, Adams PR, Sherman SM. N-methyl-D-aspartate receptors contribute to excitatory postsynaptic potentials of cat lateral geniculate neurons recorded in thalamic slices. Proc Natl Acad Sci U S A. 1990 Jun; 87(12):4548-52. View in: PubMed

  153. Uhlrich DJ, Cucchiaro JB, Humphrey AL, Sherman SM. Morphology and axonal projection patterns of individual neurons in the cat perigeniculate nucleus. J Neurophysiol. 1991 Jun; 65(6):1528-41. View in: PubMed

  154. Cucchiaro JB, Uhlrich DJ, Sherman SM. Electron-microscopic analysis of synaptic input from the perigeniculate nucleus to the A-laminae of the lateral geniculate nucleus in cats. J Comp Neurol. 1991 Aug 15; 310(3):316-36. View in: PubMed

  155. Cucchiaro JB, Bickford ME, Sherman SM. A GABAergic projection from the pretectum to the dorsal lateral geniculate nucleus in the cat. Neuroscience. 1991; 41(1):213-26. View in: PubMed

  156. Guido W, Lu SM, Sherman SM. Relative contributions of burst and tonic responses to the receptive field properties of lateral geniculate neurons in the cat. J Neurophysiol. 1992 Dec; 68(6):2199-211. View in: PubMed

  157. Lu SM, Guido W, Sherman SM. Effects of membrane voltage on receptive field properties of lateral geniculate neurons in the cat: contributions of the low-threshold Ca2+ conductance. J Neurophysiol. 1992 Dec; 68(6):2185-98. View in: PubMed

  158. Sherman SM, Wilson JR, Guillery RW. Evidence that binocular competition affects the postnatal development of Y-cells in the cat's lateral geniculate nucleus. Brain Res. 1975 Dec 19; 100(2):441-4. View in: PubMed

  159. Hoffmann KP, Sherman SM. Effects of early binocular deprivation on visual input to cat superior colliculus. J Neurophysiol. 1975 Sep; 38(5):1049-59. View in: PubMed

  160. Sherman SM, Wilson JR. Behavioral and morphological evidence for binocular competition in the postnatal development of the dog's visual system. J Comp Neurol. 1975 May 15; 161(2):183-95. View in: PubMed

  161. Sherman SM, Guillery RW. Behavioral studies of binocular competition in cats. Vision Res. 1976; 16(12):1479-81. View in: PubMed

  162. Sherman SM, Watkins DW, Wilson JR. Further differences in receptive field properties of simple and complex cells in cat striate cortex. Vision Res. 1976; 16(9):919-27. View in: PubMed

  163. Wilson JR, Sherman SM. Receptive-field characteristics of neurons in cat striate cortex: Changes with visual field eccentricity. J Neurophysiol. 1976 May; 39(3):512-33. View in: PubMed

  164. Wilson JR, Webb SV, Sherman SM. Conditions for dominance of one eye during competitive development of central connections in visually deprived cats. Brain Res. 1977 Nov 11; 136(2):277-87. View in: PubMed

  165. Norton TT, Casagrande VA, Sherman SM. Loss of Y-cells in the lateral geniculate nucleus of monocularly deprived tree shrews. Science. 1977 Aug 19; 197(4305):784-6. View in: PubMed

  166. Wilson JR, Sherman SM. Differential effects of early monocular deprivation on binocular and monocular segments of cat striate cortex. J Neurophysiol. 1977 Jul; 40(4):891-903. View in: PubMed

  167. Lin CS, Kratz KE, Sherman SM. Percentage of relay cells in the cat's lateral geniculate nucleus. Brain Res. 1977 Aug 05; 131(1):167-73. View in: PubMed

  168. Loop MS, Sherman SM. The effect of cortical lesions upon visual discriminations in binocularly deprived cats. J Comp Neurol. 1977 Jul 01; 174(1):89-94. View in: PubMed

  169. Loop MS, Sherman SM. Visual discriminations of cats with cortical and tectal lesions. J Comp Neurol. 1977 Jul 01; 174(1):79-88. View in: PubMed

  170. Sherman SM. The effect of cortical and tectal lesions on the visual fields of binocularly deprived cats. J Comp Neurol. 1977 Mar 15; 172(2):231-45. View in: PubMed

  171. Sherman SM. The effect of superior colliculus lesions upon the visual fields of cats with cortical ablations. J Comp Neurol. 1977 Mar 15; 172(2):211-29. View in: PubMed

  172. Sherman SM, Wilson JR, Kaas JH, Webb SV. X- and Y-cells in the dorsal lateral geniculate nucleus of the owl monkey (Aotus trivirgatus). Science. 1976 Apr 30; 192(4238):475-7. View in: PubMed

  173. Sherman SM, Norton TT, Casagrande VA. X- and Y-cells in the dorsal lateral geniculate nucleus of the tree shrew (Tupaia glis). Brain Res. 1975 Jul 25; 93(1):152-7. View in: PubMed

  174. Lehmkuhle S, Kratz KE, Mangel SC, Sherman SM. An effect of early monocular lid suture upon the development of X-cells in the cat's lateral geniculate nucleus. Brain Res. 1978 Nov 24; 157(2):346-50. View in: PubMed

  175. Kratz KE, Webb SV, Sherman SM. Electrophysiological classification of X- and Y-cells in the cats lateral geniculate nucleus. Vision Res. 1978; 18(9):1261-4. View in: PubMed

  176. Lin CS, Sherman SM. Effects of early monocular eyelid suture upon development of relay cell classes in the cat's lateral geniculate nucleus. J Comp Neurol. 1978 Oct 15; 181(4):809-31. View in: PubMed

  177. Kratz KE, Webb SV, Sherman SM. Effects of early monocular lid suture upon neurons in the cat's medial interlaminar nucleus. J Comp Neurol. 1978 Oct 01; 181(3):615-25. View in: PubMed

  178. Kratz KE, Webb SV, Sherman SM. Studies of the cat's medial interlaminar nucleus: a subdivision of the dorsal lateral geniculate nucleus. J Comp Neurol. 1978 Oct 01; 181(3):601-14. View in: PubMed

  179. Kratz KE, Webb SV, Sherman SM. Electrophysiological classification of X- and Y-cells in the cat's lateral geniculate nucleus. Vision Res. 1978; 18(4):489-92. View in: PubMed

  180. Watkins DW, Wilson JR, Sherman SM. Receptive-field properties of neurons in binocular and monocular segments of striate cortex in cats raised with binocular lid suture. J Neurophysiol. 1978 Mar; 41(2):322-37. View in: PubMed

  181. Sherman SM, Sprague JM. Effects of visual cortex lesions upon the visual fields of monocularly deprived cats. J Comp Neurol. 1979 Nov 15; 188(2):291-311. View in: PubMed

  182. Friedlander MJ, Lin CS, Sherman SM. Structure of physiologically identified X and Y cells in the cat's lateral geniculate nucleus. Science. 1979 Jun 08; 204(4397):1114-7. View in: PubMed

  183. Kratz KE, Sherman SM, Kalil R. Lateral geniculate nucleus in dark-reared cats: loss of Y cells without changes in cell size. Science. 1979 Mar 30; 203(4387):1353-5. View in: PubMed

  184. Sherman SM. Functional development of geniculocortical pathways in normal and amblyopic vision. Trans Ophthalmol Soc U K. 1979; 99(3):357-62. View in: PubMed